Indium (111In) biciromab

Indium (111In) biciromab?
Monoclonal antibody
Type Fab' fragment
Source Mouse
Target Fibrin II, beta chain
Clinical data
Pregnancy cat. N/A
Legal status Withdrawn
Identifiers
CAS number 138783-13-8 N
ATC code None
KEGG D03111 Y
Chemical data
Formula  ?
 N(what is this?)  (verify)

Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood.[1] It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism,[2] but was withdrawn during clinical trials.[3]

References

  1. ^ King, David J.; John R. Adair (1999). "Recombinant antibodies for the diagnosis and therapy of human disease". Current Opinion in Drug Discovery & Development 2 (2): 112. ISSN 1367-6733. 
  2. ^ Answers.com: Centocor Ortho Biotech Products, L.P.
  3. ^ DiagnosticImaging.com: Centocor withdraws imaging agent applications
Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems
Bone ("-os-", "-s(o)-")
Human ("-osu-")
Humanized ("-sozu-")
Musculoskeletal ("-mul-")
Human ("-mulu-")
Circulatory ("-c(i[r])-")
Human ("-ciru-")
Mouse ("-ciro-")
Biciromab‡ • Imciromab‡
Chimeric ("-cixi-")
Humanized ("-cizu-")
Neurologic ("-ne(u)(r)-")
Human ("-neru-")
Humanized ("-nezu-"/"-neuzu-")
Angiogenesis inhibitor ("-anibi-")
Humanized ("-anibizu-")